A 2-way miRror of red blood cells and leukemia.
نویسندگان
چکیده
In this issue of Blood, the articles by Shaham et al and Wang et al are the first to identify microRNA 486 (miR-486) as a requisite oncomiR and credible therapeutic target in myeloid leukemia of Down syndrome (ML-DS) and chronic myeloid leukemia (CML) by showing that these 2 leukemias co-opt miR-486 functions in normal erythroid progenitor progrowth and survival activity.
منابع مشابه
Onm-21: General Principles of Collecting and Storing Cord Blood Stem Cell
Cord blood is the blood that remains in the umbilical cord and placenta following birth, which is usually discarded It contains red blood cells, white blood cells, platelets, and plasma, like blood. In addition, cord blood is a rich source of stem cells that may have potentially lifesaving benefits for your baby and family. The cord blood of baby serves as an abundant source of stem cells. Thes...
متن کاملالگوریتم بهینه تقسیم‌بندی تصاویر میکروسکوپی خون برای تشخیص سلول‌های لوسمی حاد لنفوبلاست با استفاده از الگوریتم FCM و بهینه‌سازی ژنتیک
Cancer is type of disease caused by irregular, uncontrollable growth of blood cells in bone marrow. The process of generating three main blood cells including pallets, red and white blood cells, is started from a progenitor cell called as blast. Blast generates a considerable number of immature cells which are developed affected by differentiation factors. If any interruption occurs during this...
متن کاملSub-acute Exposure to Benzene Accelerates the Aging Process of Red Blood Cells; an In vivo Study
Background: The well-known toxic effects of benzene toxicity are bone marrow depression, reduction in blood cell counts, and induction of leukemia and aplastic anemia. This study was designed to evaluate biomarkers of aging in red blood cells (RBCs). Methods: Mice were exposed to benzene (50, 100, and 200 mg/kg/day) orally for 28 days. A group of benzene-exposed mice were injected intraperiton...
متن کاملOptimizing Red Blood Cells Consumption Using Markov Decision Process
In healthcare systems, one of the important actions is related to perishable products such as red blood cells (RBCs) units that its consumption management in different periods can contribute greatly to the optimality of the system. In this paper, main goal is to enhance the ability of medical community to organize the RBCs units’ consumption in way to deliver the unit order timely with a focus ...
متن کاملAMG-232, a New Inhibitor of MDM-2,Enhance Doxorubicin Efficiency in Pre-B Acute Lymphoblastic Leukemia Cells
Background: Doxorubicin (DOX)-induced cardiotoxicity appears to be a growing concern for extensive use in acute lymphoblastic leukemia (ALL). The new combination treatment strategies, therefore might be an effective way of decreasing its side effects as well as improving efficacy. AMG232 (KRT-232) is a potential MDM-2 inhibitor, increasing available p53 through disturbing p53-MDM-2 interaction....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 125 8 شماره
صفحات -
تاریخ انتشار 2015